COVENANT
Every variant classified. Every absence confirmed. Every uncertainty acknowledged.
COVENANT resolves complete human genomes in 28 seconds, classifying 38,324 variants into three deterministic states. No approximations. No silent failures. No hallucinations.
Why Three Outcomes Matter
Most genomic platforms give you two answers: found or not found.
That binary collapses a critical distinction. “Not found” could mean the variant is absent—or it could mean the region wasn't covered, the quality was too low, or the data was incomplete.
In clinical genomics, the difference between “absent” and “unknown” can change a treatment decision.
Three Deterministic States
Positive
The variant is present in the patient’s genome and meets all quality thresholds. Matched against the Hardy Bridge index with evidence attribution.
Ruled Out
The variant was evaluated and is definitively absent. Not “not found”—actively ruled out with quality confirmation. This distinction matters clinically.
Uncertain
The variant region was covered but quality metrics (GQ or DP) fell below threshold. Present but not confirmable. Flagged for follow-up, not ignored.
Performance
28s
Resolution Time
38,324
Variants Classified
100%
ACMG SF v3.2
0
Hallucinations
Quality Gates
COVENANT enforces quality at ingestion—not after the fact. Every variant passes through GS-1 Quality Gates before classification.
GQ ≥ 30
Genotype Quality score must meet or exceed 30. Variants below this threshold are classified as Uncertain, not silently dropped.
DP ≥ 20
Read Depth must meet or exceed 20. Insufficient coverage triggers Uncertain classification with explicit quality annotation.
ACMG SF v3.2
100% coverage of ACMG secondary findings list. Every reportable gene is evaluated—none skipped, none approximated.
Zero Hallucination
COVENANT is a deterministic rule engine, not a model. It cannot invent variants, infer results, or produce outputs not grounded in the input data.
Universal Format Support
COVENANT ingests clinical sequencing data and consumer genotyping files through a single unified pipeline. Every format is normalized to the same resolution standard.
Powered by the Hardy Bridge
Every variant resolved by COVENANT is matched against the Hardy Bridge index—497,000 enriched variant-to-phenotype mappings with evidence attribution, PMID citations, and guideline references.
The result is not just a list of variants. It is a clinically annotated, evidence-graded, export-ready genomic profile.
Deterministic by Design
COVENANT is not a model. It does not learn, drift, or approximate. Same input file, same logic version, same output—guaranteed.
This is not a philosophical position. It is an engineering constraint. Clinical genomics requires reproducibility. COVENANT delivers it.
Zero hallucination architecture—by construction, not by hope.
Explore COVENANT
Genome resolution that clinicians can trust—because every variant is classified, every absence confirmed, and every uncertainty acknowledged.