Infrastructure
Four Engines. One Platform.
Clinical genomics infrastructure that processes complete genomes in seconds with deterministic logic, traceable evidence, and governed outputs.
COVENANT
Genome Resolution Engine
Resolves complete human genomes in minutes. Classifies 38,324 variants into three deterministic states: Positive, Ruled Out, and Uncertain. 100% ACMG SF v3.2 secondary findings coverage with quality thresholds of GQ≥30 and DP≥20.
Minutes
Resolution
38,324
Variants
100%
ACMG SF v3.2
TRINITY
Multi-Omic Fusion Platform
Fuses genomic variants with laboratory biomarkers in 75 seconds. Cross-references 1,265,517 clinical rules to output pharmacogenomic recommendations with star alleles and PMID citations. FHIR-native export to Epic and Cerner.
75s
Fusion
1.26M+
Clinical Rules
FHIR
Native Export
PROTEUS
Evolutionary Discovery Engine
A high-performance genomic discovery engine that identifies deterministic convergence in biological systems, delivering 1,000-generation benchmarks in 130 seconds and scaling to 5,000-generation runs for deeper analysis. The same constrained interaction patterns emerge across independent runs, exposing constraint rather than randomness. Built on in-memory execution across 22.2M+ anchored molecular reference assets, with k-anonymity enforced at the SQL layer. The Study Dossier production layer converts that deterministic evidence into research-grade artifacts under closed-world AI constraints, with cryptographic provenance and validator-gated export.
1,000
Benchmark Generations
130s
Benchmark Runtime
5,000
Extended Runs
22.2M+
Anchored Molecular Reference Assets
The Hardy Bridge
Nomenclature Translation Layer
A proprietary nomenclature translation layer with 497,335 enriched variant-to-phenotype mappings. Translates seamlessly between rsIDs, HGVS notation, star alleles, chromosomal coordinates, LOINC, RxNorm, and ICD-10.
497K+
Mappings
7
Nomenclature Systems
23+
Pharmacogenes
LOINC
Clinical Vocabulary Coverage
Ancestral Adaptation
Evolutionary Medicine Engine
The first clinical genomics platform to integrate evolutionary medicine at the point of care. Ancestral Adaptation identifies variants where population frequency differences reflect ancestral selection pressures, not pathogenicity, preventing false-positive clinical alerts and enabling ancestry-aware interpretation.
Powered by gnomAD v4 population frequency data across 8 global ancestry groups, the engine computes Wright's Fst (fixation index) to quantify population differentiation for every Hardy Bridge variant. Variants with significant ancestral selection signals are annotated with evolutionary context, selection type, geographic origin, false-positive risk, and mismatch severity, then surfaced directly in clinical results, AI summaries, and the Chiron intelligence agent.
8
Population Groups
497K+
Variants Screened
Fst
Selection Metric
0%
False Positive Tolerance