NomosLogic

Infrastructure

Four Engines. One Platform.

Clinical genomics infrastructure that processes complete genomes in seconds with deterministic logic, traceable evidence, and governed outputs.

COVENANT

Genome Resolution Engine

Resolves complete human genomes in under 130 seconds. Classifies 38,324 variants into three deterministic states: Positive, Ruled Out, and Uncertain. 100% ACMG SF v3.2 secondary findings coverage with quality thresholds of GQ≥30 and DP≥20.

<130s

Resolution

38,324

Variants

100%

ACMG SF v3.2

Learn more about COVENANT

TRINITY

Multi-Omic Fusion Platform

Fuses genomic variants with laboratory biomarkers in 75 seconds. Cross-references 1,769,149 clinical rules to output pharmacogenomic recommendations with star alleles and PMID citations. FHIR-native export to Epic and Cerner.

75s

Fusion

1.76M+

Clinical Rules

FHIR

Native Export

Learn more about TRINITY

PROTEUS

Evolutionary Discovery Engine

A high-performance genomic discovery engine that identifies deterministic convergence in biological systems, delivering 1,000-generation benchmarks in 130 seconds and scaling to 5,000-generation runs for deeper analysis. The same constrained interaction patterns emerge across independent runs, exposing constraint rather than randomness. Built on in-memory execution across 23.7M+ anchored molecular reference assets, with k-anonymity enforced at the SQL layer. The Study Dossier production layer converts that deterministic evidence into research-grade artifacts under closed-world AI constraints, with cryptographic provenance and validator-gated export.

1,000

Benchmark Generations

130s

Benchmark Runtime

5,000

Extended Runs

23.7M+

Anchored Molecular Reference Assets

Learn more about PROTEUS

HEURESIS

Autonomous Discovery Engine

An autonomous discovery engine that compounds infrastructure output into testable hypotheses. Genome resolutions, multi-omic fusions, and evolutionary signals feed a closed-world reasoning loop that surfaces druggable targets, mechanism candidates, and repositioning leads with cryptographic provenance. Full architecture reserved for partners.

Closed-world

AI constraints

Signed

Cryptographic provenance

Continuous

Discovery loop

Learn more about HEURESIS

The Hardy Bridge

Nomenclature Translation Layer

A proprietary nomenclature translation layer with 497,335 enriched variant-to-phenotype mappings. Translates seamlessly between rsIDs, HGVS notation, star alleles, chromosomal coordinates, LOINC, RxNorm, and ICD-10.

497K+

Mappings

7

Nomenclature Systems

23+

Pharmacogenes

LOINC

Clinical Vocabulary Coverage

Ancestral Adaptation

Evolutionary Medicine Engine

The first clinical genomics platform to integrate evolutionary medicine at the point of care. Ancestral Adaptation identifies variants where population frequency differences reflect ancestral selection pressures, not pathogenicity, preventing false-positive clinical alerts and enabling ancestry-aware interpretation.

Powered by gnomAD v4 population frequency data across 8 global ancestry groups, the engine computes Wright's Fst (fixation index) to quantify population differentiation for every Hardy Bridge variant. Variants with significant ancestral selection signals are annotated with evolutionary context, selection type, geographic origin, false-positive risk, and mismatch severity, then surfaced directly in clinical results, AI summaries, and the Chiron intelligence agent.

8

Population Groups

497K+

Variants Screened

Fst

Selection Metric

0%

False Positive Tolerance